Nature\u2019da yay\u0131mlanan ara\u015ft\u0131rmada, obezite ve diyabet tedavisinde kullan\u0131lan semaglutidin h\u00fccresel ya\u015flanma ve ya\u015fam s\u00fcresi \u00fczerindeki etkileri incelendi. \u0130nsanlarda yakla\u015f\u0131k 60 ya\u015fa denk gelen ya\u015fl\u0131 fareler \u00fczerinde y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fmada, semaglutid uygulanan deneklerin ya\u015fam beklentisinin y\u00fczde 12,4 artt\u0131\u011f\u0131 aktar\u0131ld\u0131.<\/p>\n
Ara\u015ft\u0131rmada semaglutid verilen farelerin g\u00fcnl\u00fck g\u0131da t\u00fcketiminin y\u00fczde 24 azald\u0131\u011f\u0131 belirtildi. Ara\u015ft\u0131rmac\u0131lar, ilac\u0131n etkisini kalori k\u0131s\u0131tlamas\u0131ndan ay\u0131rabilmek amac\u0131yla ba\u015fka bir fare grubuna da ayn\u0131 oranda do\u011frudan kalori k\u0131s\u0131tlamas\u0131 uygulad\u0131. \u0130ki grubun benzer miktarda kilo ve ya\u011f k\u00fctlesi kaybetti\u011fi, ancak yeme davran\u0131\u015flar\u0131 ve baz\u0131 biyolojik g\u00f6stergelerde farkl\u0131l\u0131klar bulundu\u011fu bildirildi.<\/p>\n
Semaglutid uygulanan farelerde NAD+ seviyelerinin y\u00fckseldi\u011fi, hipokampusta yeni sinir h\u00fccresi olu\u015fumunun artt\u0131\u011f\u0131, mekansal haf\u0131zan\u0131n g\u00fc\u00e7lendi\u011fi ve kronik enflamasyon ile ya\u015flanm\u0131\u015f h\u00fccre birikiminin azald\u0131\u011f\u0131 saptand\u0131. Kalori k\u0131s\u0131tlamas\u0131 uygulanan grupta da fiziksel performans ve kas\/ya\u011f oran\u0131nda iyile\u015fme g\u00f6r\u00fcld\u00fc\u011f\u00fc, semaglutid grubunun ise baz\u0131 haf\u0131za ve hareketlilik testlerinde daha y\u00fcksek performans g\u00f6sterdi\u011fi aktar\u0131ld\u0131.<\/p>\n
Medicana Atak\u00f6y Hastanesi \u0130\u00e7 Hastal\u0131klar\u0131 Uzman\u0131 Dr. Burak Uzel, \u00e7al\u0131\u015fman\u0131n hayvan modellerinde ger\u00e7ekle\u015ftirildi\u011fine dikkat \u00e7ekerek bulgular\u0131n do\u011frudan insanlara uyarlanamayaca\u011f\u0131n\u0131 ifade etti.<\/p>\n
Uzel, \u201cNature’da yay\u0131mlanan bu \u00e7al\u0131\u015fma bize iki \u00f6nemli mesaj veriyor. Birincisi; besin yetersizli\u011fine (maln\u00fcsyona) yol a\u00e7mayacak \u015fekilde kalori al\u0131m\u0131n\u0131 d\u00fc\u015f\u00fcrmek, biyolojik ya\u015flanmay\u0131 yava\u015flatan en g\u00fc\u00e7l\u00fc mekanizmalardan biridir. Kalori k\u0131s\u0131tlamas\u0131 yap\u0131lan farelerde de t\u0131pk\u0131 ila\u00e7 grubunda oldu\u011fu gibi belirgin bir fiziki din\u00e7lik ve metabolik iyile\u015fme g\u00f6zlendi.\u201d dedi.<\/p>\n
Uzel, s\u00f6zlerini \u015f\u00f6yle s\u00fcrd\u00fcrd\u00fc: \u201c\u0130kinci ve en pratik mesaj ise g\u00fcn i\u00e7inde t\u00fcketti\u011fimiz porsiyonlar\u0131n b\u00fcy\u00fckl\u00fc\u011f\u00fcyle ilgilidir. \u0130ster GLP-1 resept\u00f6r agonistleri gibi modern medikal tedavilerle ister bilin\u00e7li beslenme tercihleriyle olsun; porsiyonlar\u0131 makul seviyelerde tutmak ve gereksiz kalori y\u00fck\u00fcn\u00fc azaltmak, h\u00fccresel d\u00fczeyde yenilenmeyi destekleyerek daha sa\u011fl\u0131kl\u0131 bir ya\u015flanma s\u00fcrecinin kap\u0131s\u0131n\u0131 aralamaktad\u0131r.\u201d<\/p>\n
\n
<\/strong> Nature\u2019da yay\u0131mlanan ara\u015ft\u0131rmada, semaglutid uygulanan ya\u015fl\u0131 farelerin ya\u015fam beklentisinde y\u00fczde 12,4 art\u0131\u015f g\u00f6zlendi\u011fi bildirildi. Medicana Atak\u00f6y Hastanesi \u0130\u00e7 Hastal\u0131klar\u0131 Uzman\u0131 Dr. Burak Uzel, bulgular\u0131n insanlara do\u011frudan uyarlanamayaca\u011f\u0131n\u0131 belirtti.<\/p>\n","protected":false},"author":1,"featured_media":153328,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAow07ekDA:productID":"","footnotes":""},"categories":[4],"tags":[],"class_list":["post-153327","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"_links":{"self":[{"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/153327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=153327"}],"version-history":[{"count":0,"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/153327\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/media\/153328"}],"wp:attachment":[{"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=153327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=153327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ekonomigundemi.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=153327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nEKONOM\u0130 GAZETES\u0130 <\/p>\n","protected":false},"excerpt":{"rendered":"